secretaria.seprot@gmail.com
flagEnglish
flagEspañol
Facebook
Twitter
SEPROT
  • NOVEDADES
  • CURSOS Y CONGRESOS
  • TRABAJO
  • BECAS
  • PUBLICACIONES
  • ENLACES
  • AGENDA
  • ARCHIVO
  • QUIÉNES SOMOS
  • SOCIOS
  • CONTACTO

Artículo: Dissection of two routes to naïve pluripotency using different kinase inhibitors del grupo de J. Muñoz (CNIO)

5 abril, 2021Articulos Socios SEProt, Noticiasadmin

Dissection of two routes to naïve pluripotency using different kinase inhibitors
Ana Martinez-Val, Cian J. Lynch, Isabel Calvo, Pilar Ximénez-Embún, Fernando Garcia, Eduardo Zarzuela, Manuel Serrano & Javier Muñoz

Nature Communications volume 12, Article number: 1863 (2021)

Abstract:
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimulates enhancers and, similar to 2i, stabilizes ESCs in the naïve state. Here, we use mass spectrometry to describe the molecular events (phosphoproteome, proteome, and metabolome) triggered by 2i and Cdk8/19i on ESCs. Our data reveal widespread commonalities between these two treatments, suggesting overlapping processes. We find that post-transcriptional de-repression by both 2i and Cdk8/19i might support the mitochondrial capacity of naive cells. However, proteome reprogramming in each treatment is achieved by different mechanisms. Cdk8/19i acts directly on the transcriptional machinery, activating key identity genes to promote the naïve program. In contrast, 2i stabilizes the naïve circuitry through, in part, de-phosphorylation of downstream transcriptional effectors.

Enlace: https://www.nature.com/articles/s41467-021-22181-5

Publicación anterior Inauguramos una nueva sección en nuestra web: Artículos de los socios de la SEProt Siguiente publicación Fallo del octavo premio de la Sociedad Española de Proteómica – Premio Juan Pablo Albar

ESTAMOS EN

Facebook
Twitter

LO ÚLTIMO

  • Jornada SEProt – Proteo Vilamoura 2022
  • ProteoVilamoura – 2nd Joint Meeting of Spanish, French, and Portuguese Proteomics Societies
  • Dysregulated protein phosphorylation: A determining condition in the continuum of brain aging and Alzheimer’s disease. E Santamaría’s Lab (UPNA-IdiSNA)

OFERTAS DE TRABAJO

  • Bioinformatician in Mass Spectrometry-based Proteogenomics – Mnemo Therapeutics
  • Sustitución titulado superior de apoyo a la investigación con creación de bolsa de empleo
  • Oferta de Trabajo: Candidato/a para solicitar ayuda Sara Borrell, Grupo Dra. Ruiz-Romero, INIBIC

CURSOS Y CONGRESOS

  • Webinar: Infection Medicine, new-old approaches and perspectives
  • «HUPO Proteomics Fundamentals Pre-Congress Training Course”
  • Jornada UCO-Bruker Imaging
  • CURSO DE PROTEÓMICA CLÍNICA
  • II Curso de Proteómica Clínica ProteoRed
  • II Clinical Proteomics Course (ProteoRed)

CONTACTO

Sociedad Española de Proteómica C/. Jaime Roig 11 46010 Valencia
secretaria@seprot.es

ESTAMOS EN

Facebook
Twitter

LO ÚLTIMO

  • Jornada SEProt – Proteo Vilamoura 2022
  • Bioinformatician in Mass Spectrometry-based Proteogenomics – Mnemo Therapeutics
  • Sustitución titulado superior de apoyo a la investigación con creación de bolsa de empleo

ENLACES

ProteoRed

precarios

Aviso Legal | Diseño Prisma
Esta web utiliza cookies para mejorar su experiencia Acepto Leer más
Política de cookies

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Siempre activado

Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.

Non-necessary

Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.

GUARDAR Y ACEPTAR